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Tianjin Cancer Institute<span>></span>Research<span>></span>Our Researchers
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<div class="contant">
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<img src="../images/lixiangchun.png" alt="" />
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<div class="contant_name">
Prof. Xiangchun Li
</div>
<div class="contant_names">
Professor of Department of Public Laboratory
</div>
</div>
</div>
<div class="contant_word">
<div class="contant_title">Education:</div>
<div class="contant_words">
2006.9-2010.7 Bachelor of Engineering in Bioinformation Technology, Huazhong University of Science and Technology,
</div>
<div class="contant_words">
2012.8~2016.12 Ph.D in Medical Sciences, Chinese University of Hong Kong,
</div>
<div class="contant_title">Professional Experiences:</div>
<div class="contant_words">
2010.7~2012.8 NGS data analyst, Beijing Genomics Institute, Shenzhen,
</div>
<div class="contant_words">
2017.2~present Professor, Tianjin Cancer Institute, Tianjin Medical University Cancer Institute and Hospital,
</div>
<div class="contant_title">
Research Focus
</div>
<div class="contant_words">
Our research focuses on characterizing mutational landscape of human gastrointestinal cancer, elucidating the association between mutational footprints and environmental factors, identifying biomarkers with translational significance in immunotherapy
and early cancer diagnosis, and interpreting medical imaging data using deep learning algorithms. Through bioinformatics analyses, we identified new driver genes underlying the development of gastrointestinal cancer, and shed new
lights on genetic markers that are potentially clinically actionable. By applying deep learning algorithm to analyze large-scale sonographic imaging data, we developed a deep learning model that could augment radiologists’ ability
in thyroid cancer diagnosis. We have published more than 20 peer-reviewed articles in international journals, including Lancet Oncology, JAMA Oncology, and Annals of Oncology etc.
</div>
<div class="contant_title">Selected Publications</div>
<div class="contant_words">
1. Li X#, Zhang S#, Zhang Q#, Wei X#, Pan Y, Zhao J, Xin X, Qin C, Wang X, Li J, Yang F, Zhao Y, Yang M, Wang Q, Zheng Z, Zheng X, Yang X, Whitlow CT, Gurcan MN, Zhang L, Wang X, Pasche BC, Gao M, Zhang W*, Chen K*. Diagnosis of thyroid cancer using deep
convolutional neural network models applied to sonographic images: a retrospective, multicohort, diagnostic study. Lancet Oncol. 2019 Feb;20(2):193-201. <span>doi: 10.1016/S1470-2045(18)30762-9.</span> Epub
2018 Dec 21.
</div>
<div class="contant_words">
2. Li X#, Pasche B, Zhang W*, Chen K*. Association of MUC16 Mutation With Tumor Mutation Load and Outcomes in Patients With Gastric Cancer. JAMA Oncol. 2018 Dec 1;4(12):1691-1698. <span>doi: 10.1001/jamaoncol.2018.2805.</span> PubMed PMID: 30098163.
</div>
<div class="contant_words">
3. Li X#, Wang MY, Yang M, Dai HJ, Zhang BF, Wang W, Chu XL, Wang X, Zheng H, Niu RF, Zhang W*, Chen KX*. A mutational signature associated with alcohol consumption and prognostically significantly mutated driver genes in esophageal squamous cell carcinoma.
Ann Oncol. 2018 Apr 1;29(4):938-944. <span>doi: 10.1093/annonc/mdy011.</span> PubMed PMID: 29351612; PubMed Central PMCID: PMC5913594.
</div>
<div class="contant_words">
4. Chen K#, Yang D#, Li X#, Sun B, Song F, Cao W, Brat DJ, Gao Z, Li H, Liang H, Zhao Y, Zheng H, Li M, Buckner J, Patterson SD, Ye X, Reinhard C, Bhathena A, Joshi D, Mischel PS, Croce CM, Wang YM, Raghavakaimal S, Li H, Lu X, Pan Y, Chang H, Ba S, Luo
L, Cavenee WK*, Zhang W*, Hao X*. Mutational landscape of gastric adenocarcinoma in Chinese: implications for prognosis and therapy. Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1107-12. <span>doi: 10.1073/pnas.1422640112.</span> Epub 2015 Jan 12. PubMed PMID: 25583476; PubMed Central PMCID: PMC4313862.
</div>
<div class="contant_words">
5. Song Y#, Li L#, Ou Y#, Gao Z#, Li E#, Li X#, Zhang W, Wang J, Xu L, Zhou Y, Ma X, Liu L, Zhao Z, Huang X, Fan J, Dong L, Chen G, Ma L, Yang J, Chen L, He M, Li M, Zhuang X, Huang K, Qiu K, Yin G, Guo G, Feng Q, Chen P, Wu Z, Wu J, Ma L, Zhao J, Luo
L, Fu M, Xu B, Chen B, Li Y, Tong T, Wang M, Liu Z, Lin D, Zhang X, Yang H, Wang J, Zhan Q*. Identification of genomic alterations in oesophageal squamous cell cancer. Nature. 2014 May 1;509(7498):91-5. <span>doi: 10.1038/nature13176.</span> Epub 2014 Mar 16. PubMed PMID: 24670651.
</div>
<div class="contant_words">
6. Wang X#, Li X#, Zhang L#, Wong SH, Wang MHT, Tse G, Dai RZW, Nakatsu G, Coker OO, Chen Z, Ko H, Chan JYK, Liu T, Cheng CHK, Cheng ASL, To KF, Plewczynski D, Sung JJY, Yu J, Gin T*, Chan MTV*, Wu WKK*. Oncogenes expand during evolution to withstand
somatic amplification. Ann Oncol. 2018 Nov 1;29(11):2254-2260. <span>doi: 10.1093/annonc/mdy397.</span> PubMed PMID: 30204835.
</div>
<div class="contant_words">
7. Li X#, Xu W#, Kang W, Wong SH, Wang M, Zhou Y, Fang X, Zhang X, Yang H, Wong CH, To KF, Chan SL, Chan MTV, Sung JJY, Wu WKK*, Yu J*. Genomic analysis of liver cancer unveils novel driver genes and distinct prognostic features. Theranostics. 2018;8(6):1740-1751.
<span>doi: 10.7150/thno.22010.</span> eCollection 2018. PubMed PMID: 29556353; PubMed Central PMCID: PMC5858179.
</div>
<div class="contant_words">
8. Li X#, Wu WK*, Xing R, Wong SH, Liu Y, Fang X, Zhang Y, Wang M, Wang J, Li L, Zhou Y, Tang S, Peng S, Qiu K, Chen L, Chen K, Yang H, Zhang W, Chan MT, Lu Y, Sung JJ, Yu J*. Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include
Novel Mutational Signatures with Prognostic Capability. Cancer Res. 2016 Apr 1;76(7):1724-32. <span>doi: 10.1158/0008-5472.CAN-15-2443.</span> Epub 2016 Feb 8. PubMed PMID: 26857262.
</div>
<div class="contant_words">
9. Nakatsu G#, Li X#, Zhou H#, Sheng J#, Wong SH#, Wu WK#, Ng SC, Tsoi H, Dong Y, Zhang N, He Y, Kang Q, Cao L, Wang K, Zhang J, Liang Q, Yu J*, Sung JJ*. Gut mucosal microbiome across stages of colorectal carcinogenesis. Nat Commun. 2015 Oct 30;6:8727.
<span>doi: 10.1038/ncomms9727.</span> PubMed PMID: 26515465; PubMed Central PMCID: PMC4640069.
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